SCOPe 2.08: Domain d2orva1: 2orv A:18-150

Lineage for d2orva1 (2orv A:18-150)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.24: Type II thymidine kinase [117558] (2 proteins)
   N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)

6. Protein Thymidine kinase, TK1, N-terminal domain [117559] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117560] (2 PDB entries)
   Uniprot P04183 18-191

8. Domain d2orva1: 2orv A:18-150 [139274]
   Other proteins in same PDB: d2orva2, d2orvb2
   automated match to d1xbta1
   complexed with 4ta, zn

Details for d2orva1

PDB Entry: 2orv, 2.3 Å

PDB Description: human thymidine kinase 1 in complex with tp4a

PDB Compounds: (A:) Thymidine kinase

SCOPe Domain Sequences for d2orva1:

Sequence, based on SEQRES records:

>d2orva1 c.37.1.24 (A:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssfcthdrntmealp
acllrdvaqealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgail
nlvplaesvvklt

Sequence, based on observed residues (ATOM records):

>d2orva1 c.37.1.24 (A:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrymealpacllrdvaqea
lgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvk
lt

Timeline for d2orva1:

• d2orva1 first appeared in SCOP 1.73
  
• d2orva1 appears in SCOPe 2.07