Lineage for d2orva1 (2orv A:18-150)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2109203Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2109204Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2113830Family c.37.1.24: Type II thymidine kinase [117558] (2 protein domains)
    N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)
  6. 2113831Protein Thymidine kinase, TK1, N-terminal domain [117559] (4 species)
  7. 2113835Species Human (Homo sapiens) [TaxId:9606] [117560] (2 PDB entries)
    Uniprot P04183 18-191
  8. 2113844Domain d2orva1: 2orv A:18-150 [139274]
    Other proteins in same PDB: d2orva2, d2orvb2
    automated match to d1xbta1
    complexed with 4ta, zn

Details for d2orva1

PDB Entry: 2orv (more details), 2.3 Å

PDB Description: human Thymidine Kinase 1 in complex with TP4A
PDB Compounds: (A:) Thymidine kinase

SCOPe Domain Sequences for d2orva1:

Sequence, based on SEQRES records: (download)

>d2orva1 c.37.1.24 (A:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssfcthdrntmealp
acllrdvaqealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgail
nlvplaesvvklt

Sequence, based on observed residues (ATOM records): (download)

>d2orva1 c.37.1.24 (A:18-150) Thymidine kinase, TK1, N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrymealpacllrdvaqea
lgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvk
lt

SCOPe Domain Coordinates for d2orva1:

Click to download the PDB-style file with coordinates for d2orva1.
(The format of our PDB-style files is described here.)

Timeline for d2orva1:

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Domains from same chain:
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d2orva2