SCOP 1.73: Domain d2onld1: 2onl D:46-385

Lineage for d2onld1 (2onl D:46-385)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (5 PDB entries)

8. Domain d2onld1: 2onl D:46-385 [139161]
   Other proteins in same PDB: d2onla1, d2onlb1
   automatically matched to d1kwpa_

Details for d2onld1

PDB Entry: 2onl, 4 Å

PDB Description: crystal structure of the p38a-mapkap kinase 2 heterodimer

PDB Compounds: (D:) MAP kinase-activated protein kinase 2

SCOP Domain Sequences for d2onld1:

Sequence, based on SEQRES records:

>d2onld1 d.144.1.7 (D:46-385) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterease
imksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcy
tpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqye
fpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked
kerwedvkeemtsalatmrvdyeqikikkiedasnplllk

Sequence, based on observed residues (ATOM records):

>d2onld1 d.144.1.7 (D:46-385) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcphivri
vdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqylhsi
niahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlgpeky
dkscdmwslgvimyillcgyppfyefpnpewsevseevkmlirnllkteptqrmtitefm
nhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmrvdyeqikikkiedasn
plllk

Timeline for d2onld1:

• d2onld1 is new in SCOP 1.73
  
• d2onld1 appears in SCOP 1.75
  
• d2onld1 appears in the current release, SCOPe 2.08