SCOPe 2.08: Domain d2onlc1: 2onl C:46-385

Lineage for d2onlc1 (2onl C:46-385)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase activated protein kinase 2, mapkap2 [82789] (1 species)
   CaMK group; MAPKAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82790] (16 PDB entries)

8. Domain d2onlc1: 2onl C:46-385 [139160]
   Other proteins in same PDB: d2onla1, d2onlb1
   automatically matched to d1kwpa_

Details for d2onlc1

PDB Entry: 2onl, 4 Å

PDB Description: crystal structure of the p38a-mapkap kinase 2 heterodimer

PDB Compounds: (C:) MAP kinase-activated protein kinase 2

SCOPe Domain Sequences for d2onlc1:

Sequence, based on SEQRES records:

>d2onlc1 d.144.1.7 (C:46-385) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarrev
elhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterease
imksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcy
tpyyvapevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqye
fpnpewsevseevkmlirnllkteptqrmtitefmnhpwimqstkvpqtplhtsrvlked
kerwedvkeemtsalatmrvdyeqikikkiedasnplllk

Sequence, based on observed residues (ATOM records):

>d2onlc1 d.144.1.7 (C:46-385) MAP kinase activated protein kinase 2, mapkap2 {Human (Homo sapiens) [TaxId: 9606]}
fhvksglqikknaiiddykvkvlqifnkrtqekfalkmlqdcpkarrevelhwrasqcph
ivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereaseimksigeaiqy
lhsiniahrdvkpenllytskrpnailkltdfgfakettshnslttpcytpyyvapevlg
pekydkscdmwslgvimyillcgyppfyefpnpewsevseevkmlirnllkteptqrmti
tefmnhpwimqstkvpqtplhtsrvlkedkerwedvkeemtsalatmrvdyeqikikkie
dasnplllk

Timeline for d2onlc1:

• d2onlc1 first appeared in SCOP 1.73
  
• d2onlc1 appears in SCOPe 2.07