SCOPe 2.06: Domain d2onlb1: 2onl B:4-352

Lineage for d2onlb1 (2onl B:4-352)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (185 PDB entries)

8. Domain d2onlb1: 2onl B:4-352 [139159]
   Other proteins in same PDB: d2onlc1, d2onld1
   automatically matched to d1a9u__

Details for d2onlb1

PDB Entry: 2onl, 4 Å

PDB Description: crystal structure of the p38a-mapkap kinase 2 heterodimer

PDB Compounds: (B:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2onlb1:

Sequence, based on SEQRES records:

>d2onlb1 d.144.1.7 (B:4-352) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d2onlb1 d.144.1.7 (B:4-352) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglaratrwyrapei
mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
sarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
pddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d2onlb1:

• d2onlb1 first appeared in SCOP 1.73
  
• d2onlb1 appears in SCOPe 2.05
  
• d2onlb1 appears in SCOPe 2.07
  
• d2onlb1 appears in the current release, SCOPe 2.08