SCOPe 2.08: Domain d2og8b2: 2og8 B:237-499

Lineage for d2og8b2 (2og8 B:237-499)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Lymphocyte kinase (lck) [56153] (1 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56154] (35 PDB entries)

8. Domain d2og8b2: 2og8 B:237-499 [139062]
   Other proteins in same PDB: d2og8b3, d2og8b4
   automated match to d1qpca_
   complexed with 1n8

Details for d2og8b2

PDB Entry: 2og8, 2.3 Å

PDB Description: crystal structure of aminoquinazoline 36 bound to Lck

PDB Compounds: (B:) Proto-oncogene tyrosine-protein kinase LCK

SCOPe Domain Sequences for d2og8b2:

Sequence, based on SEQRES records:

>d2og8b2 d.144.1.7 (B:237-499) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
ewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlq
hqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafie
ernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtapeainygt
ftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlc
wkerpedrptfdylrsvledfft

Sequence, based on observed residues (ATOM records):

>d2og8b2 d.144.1.7 (B:237-499) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
ewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlq
hqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafie
ernyihrdlraanilvsdtlsckiadfglapikwtapeainygtftiksdvwsfgillte
ivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerpedrptfdylrs
vledfft

Timeline for d2og8b2:

• d2og8b2 first appeared in SCOP 1.73, called d2og8b1
  
• d2og8b2 appears in SCOPe 2.07