Lineage for d2ofva1 (2ofv A:231-498)

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 734668Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 734669Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 734710Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 735250Protein Lymphocyte kinase (lck) [56153] (1 species)
    PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase
  7. 735251Species Human (Homo sapiens) [TaxId:9606] [56154] (10 PDB entries)
  8. 735259Domain d2ofva1: 2ofv A:231-498 [139057]
    automatically matched to d1qpca_
    complexed with 242

Details for d2ofva1

PDB Entry: 2ofv (more details), 2 Å

PDB Description: crystal structure of aminoquinazoline 1 bound to Lck
PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase LCK

SCOP Domain Sequences for d2ofva1:

Sequence, based on SEQRES records: (download)

>d2ofva1 d.144.1.7 (A:231-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
kpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaean
lmkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiae
gmafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtape
ainygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeely
qlmrlcwkerpedrptfdylrsvledff

Sequence, based on observed residues (ATOM records): (download)

>d2ofva1 d.144.1.7 (A:231-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
kpwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqglaeanlmkqlqh
qrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafiee
rnyihrdlraanilvsdtlsckiadfglaikwtapeainygtftiksdvwsfgillteiv
thgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerpedrptfdylrsvl
edff

SCOP Domain Coordinates for d2ofva1:

Click to download the PDB-style file with coordinates for d2ofva1.
(The format of our PDB-style files is described here.)

Timeline for d2ofva1: