SCOPe 2.08: Domain d2ofva2: 2ofv A:232-498

Lineage for d2ofva2 (2ofv A:232-498)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Lymphocyte kinase (lck) [56153] (1 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56154] (35 PDB entries)

8. Domain d2ofva2: 2ofv A:232-498 [139057]
   Other proteins in same PDB: d2ofva3, d2ofvb3
   automated match to d1qpca_
   complexed with 242

Details for d2ofva2

PDB Entry: 2ofv, 2 Å

PDB Description: crystal structure of aminoquinazoline 1 bound to Lck

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase LCK

SCOPe Domain Sequences for d2ofva2:

Sequence, based on SEQRES records:

>d2ofva2 d.144.1.7 (A:232-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
pwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanl
mkqlqhqrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaeg
mafieernyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtapea
inygtftiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyq
lmrlcwkerpedrptfdylrsvledff

Sequence, based on observed residues (ATOM records):

>d2ofva2 d.144.1.7 (A:232-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
pwwedewevpretlklverlgagqfgevwmgyynghtkvavkslkqglaeanlmkqlqhq
rlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafieer
nyihrdlraanilvsdtlsckiadfglaikwtapeainygtftiksdvwsfgillteivt
hgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwkerpedrptfdylrsvle
dff

Timeline for d2ofva2:

• d2ofva2 first appeared in SCOP 1.73, called d2ofva1
  
• d2ofva2 appears in SCOPe 2.07