SCOPe 2.08: Domain d2ofpb2: 2ofp B:1-167

Lineage for d2ofpb2 (2ofp B:1-167)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (19 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

6. Protein Ketopantoate reductase PanE [69419] (1 species)

7. Species Escherichia coli [TaxId:562] [69420] (4 PDB entries)

8. Domain d2ofpb2: 2ofp B:1-167 [139055]
   Other proteins in same PDB: d2ofpa1, d2ofpa3, d2ofpb1, d2ofpb3
   automated match to d1ks9a2
   complexed with act, dio, nap, paf

Details for d2ofpb2

PDB Entry: 2ofp, 2.3 Å

PDB Description: Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate

PDB Compounds: (B:) Ketopantoate reductase

SCOPe Domain Sequences for d2ofpb2:

Sequence; same for both SEQRES and ATOM records:

>d2ofpb2 c.2.1.6 (B:1-167) Ketopantoate reductase PanE {Escherichia coli [TaxId: 562]}
mkitvlgcgalgqlwltalckqghevqgwlrvpqpycsvnlvetdgsifnesltandpdf
latsdlllvtlkawqvsdavkslastlpvttpillihngmgtieelqniqqpllmgttth
aarrdgnviihvangithigparqqdgdysyladilqtvlpdvawhn

Timeline for d2ofpb2:

• d2ofpb2 first appeared in SCOP 1.73
  
• d2ofpb2 appears in SCOPe 2.07