SCOP 1.73: Domain d2of0a1: 2of0 A:-1-385

Lineage for d2of0a1 (2of0 A:-1-385)

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (30 PDB entries)

8. Domain d2of0a1: 2of0 A:-1-385 [139041]
   automatically matched to d1fkna_
   complexed with cmz, dms, iod; mutant

Details for d2of0a1

PDB Entry: 2of0, 2.25 Å

PDB Description: x-ray crystal structure of beta secretase complexed with compound 5

PDB Compounds: (A:) Beta-secretase 1

SCOP Domain Sequences for d2of0a1:

Sequence, based on SEQRES records:

>d2of0a1 b.50.1.2 (A:-1-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d2of0a1 b.50.1.2 (A:-1-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgaasvggsmiiggidhslytgsl
wytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksi
kaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrp
vedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrta
avegpfvtldmedcgyn

Timeline for d2of0a1:

• d2of0a1 is new in SCOP 1.73
  
• d2of0a1 appears in SCOP 1.75
  
• d2of0a1 appears in the current release, SCOPe 2.08, called d2of0a_