SCOP 1.75: Domain d2oc2a1: 2oc2 A:40-618

Lineage for d2oc2a1 (2oc2 A:40-618)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (17 families)

5. Family d.92.1.5: Neurolysin-like [55505] (4 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Angiotensin converting enzyme, ACE [82733] (2 species)
   M2 family member; overall fold is similar to that of neurolysin but is less elaborated

7. Species Human (Homo sapiens) [TaxId:9606] [82734] (5 PDB entries)
   Uniprot P22966

8. Domain d2oc2a1: 2oc2 A:40-618 [139007]
   automatically matched to d1o86a_
   complexed with cl, rx3, zn

Details for d2oc2a1

PDB Entry: 2oc2, 2.25 Å

PDB Description: Structure of testis ACE with RXPA380

PDB Compounds: (A:) Angiotensin-converting enzyme, somatic isoform

SCOP Domain Sequences for d2oc2a1:

Sequence, based on SEQRES records:

>d2oc2a1 d.92.1.5 (A:40-618) Angiotensin converting enzyme, ACE {Human (Homo sapiens) [TaxId: 9606]}
deaeaskfveeydrtsqvvwneyaeanwnyntnittetskillqknmqianhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpngscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwnks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkiafip
fsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvp
yiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamq
litgqpnmsasamlsyfkplldwlrtenelhgeklgwpq

Sequence, based on observed residues (ATOM records):

>d2oc2a1 d.92.1.5 (A:40-618) Angiotensin converting enzyme, ACE {Human (Homo sapiens) [TaxId: 9606]}
deaeaskfveeydrtsqvvwneyaeanwnyntnittetskillqknmqianhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpngscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwnks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllssggsdehdinflmkmaldkiafipf
sylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvpy
iryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamql
itgqpnmsasamlsyfkplldwlrtenelhgeklgwpq

Timeline for d2oc2a1:

• d2oc2a1 first appeared in SCOP 1.73
  
• d2oc2a1 is called d2oc2a_ in SCOPe 2.01
  
• d2oc2a1 appears in the current release, SCOPe 2.08, called d2oc2a_