SCOP 1.73: Domain d2o23b1: 2o23 B:6-253

Lineage for d2o23b1 (2o23 B:6-253)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102152] (3 PDB entries)

8. Domain d2o23b1: 2o23 B:6-253 [138885]
   automatically matched to d1so8a_
   complexed with gol, nad

Details for d2o23b1

PDB Entry: 2o23, 1.2 Å

PDB Description: the structure of wild-type human hadh2 (17beta-hydroxysteroid dehydrogenase type 10) bound to nad+ at 1.2 a

PDB Compounds: (B:) HADH2 protein

SCOP Domain Sequences for d2o23b1:

Sequence, based on SEQRES records:

>d2o23b1 c.2.1.2 (B:6-253) Type II 3-hydroxyacyl-CoA dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
rsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadv
tsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgt
fnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiard
lapigirvmtiapglfgtplltslpekvcnflasqvpfpsrlgdpaeyahlvqaiienpf
lngevirl

Sequence, based on observed residues (ATOM records):

>d2o23b1 c.2.1.2 (B:6-253) Type II 3-hydroxyacyl-CoA dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
rsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadv
tsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgt
fnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiard
lapigirvmtiapglfgtpllnflasqvpfpsrlgdpaeyahlvqaiienpflngevirl

Timeline for d2o23b1:

• d2o23b1 is new in SCOP 1.73
  
• d2o23b1 appears in SCOP 1.75
  
• d2o23b1 appears in the current release, SCOPe 2.08, called d2o23b2