Lineage for d2o23a2 (2o23 A:6-261)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2091795Protein automated matches [190085] (51 species)
    not a true protein
  7. 2091971Species Human (Homo sapiens) [TaxId:9606] [186828] (23 PDB entries)
  8. 2091972Domain d2o23a2: 2o23 A:6-261 [138884]
    Other proteins in same PDB: d2o23a3, d2o23b3
    automated match to d1u7ta_
    complexed with gol, nad

Details for d2o23a2

PDB Entry: 2o23 (more details), 1.2 Å

PDB Description: the structure of wild-type human hadh2 (17beta-hydroxysteroid dehydrogenase type 10) bound to nad+ at 1.2 a
PDB Compounds: (A:) HADH2 protein

SCOPe Domain Sequences for d2o23a2:

Sequence, based on SEQRES records: (download)

>d2o23a2 c.2.1.2 (A:6-261) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadv
tsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgt
fnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiard
lapigirvmtiapglfgtplltslpekvcnflasqvpfpsrlgdpaeyahlvqaiienpf
lngevirldgairmqp

Sequence, based on observed residues (ATOM records): (download)

>d2o23a2 c.2.1.2 (A:6-261) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rsvkglvavitggasglglataerlvgqgasavlldlpnsggeaqakklgnncvfapadv
tsekdvqtalalakgkfgrvdvavncagiavasktynlkkgqthtledfqrvldvnlmgt
fnvirlvagemgqnepdqggqrgviintasvaafegqvgqaaysaskggivgmtlpiard
lapigirvmtiapglfgtpnflasqvpfpsrlgdpaeyahlvqaiienpflngevirldg
airmqp

SCOPe Domain Coordinates for d2o23a2:

Click to download the PDB-style file with coordinates for d2o23a2.
(The format of our PDB-style files is described here.)

Timeline for d2o23a2:

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Domains from same chain:
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d2o23a3