SCOPe 2.08: Domain d2o1ya2: 2o1y A:5-215

Lineage for d2o1ya2 (2o1y A:5-215)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein Apoptosis regulator Bcl-xL [56856] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56857] (51 PDB entries)

8. Domain d2o1ya2: 2o1y A:5-215 [138881]
   Other proteins in same PDB: d2o1ya3, d2o1ya4
   automated match to d1g5ja_
   complexed with 43b
   has additional insertions and/or extensions that are not grouped together

Details for d2o1ya2

PDB Entry: 2o1y

PDB Description: solution structure of the anti-apoptotic protein bcl-xl in complex with an acyl-sulfonamide-based ligand

PDB Compounds: (A:) apoptosis regulator bcl-x

SCOPe Domain Sequences for d2o1ya2:

Sequence; same for both SEQRES and ATOM records:

>d2o1ya2 f.1.4.1 (A:5-215) Apoptosis regulator Bcl-xL {Human (Homo sapiens) [TaxId: 9606]}
msqsnrelvvdflsyklsqkgyswsqfsdveenrteapegteseavkqalreagdefelr
yrrafsdltsqlhitpgtayqsfeqvvnelfrdgvnwgrivaffsfggalcvesvdkemq
vlvsriaawmatylndhlepwiqenggwdtfvelygnnaaaesrkgqerle

Timeline for d2o1ya2:

• d2o1ya2 first appeared in SCOP 1.73, called d2o1ya1
  
• d2o1ya2 appears in SCOPe 2.07