SCOPe 2.06: Domain d2nyra_: 2nyr A:

Lineage for d2nyra_ (2nyr A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase sirtuin-5 [142128] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [142129] (4 PDB entries)
   Uniprot Q9NXA8 36-302

8. Domain d2nyra_: 2nyr A: [138827]
   automated match to d2b4ya1
   complexed with svr, zn

Details for d2nyra_

PDB Entry: 2nyr, 2.06 Å

PDB Description: Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin

PDB Compounds: (A:) NAD-dependent deacetylase sirtuin-5

SCOPe Domain Sequences for d2nyra_:

Sequence, based on SEQRES records:

>d2nyra_ c.31.1.5 (A:) NAD-dependent deacetylase sirtuin-5 {Human (Homo sapiens) [TaxId: 9606]}
psssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafahnp
srvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknll
eihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggl
lrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefn
tettpatnrfrfhfqgpcgttlpeala

Sequence, based on observed residues (ATOM records):

>d2nyra_ c.31.1.5 (A:) NAD-dependent deacetylase sirtuin-5 {Human (Homo sapiens) [TaxId: 9606]}
psssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafahnp
srvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknll
eihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcggl
lrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaefn
terfhfqgpcgttlpeala

Timeline for d2nyra_:

• d2nyra_ first appeared in SCOP 1.73, called d2nyra1
  
• d2nyra_ appears in SCOPe 2.05
  
• d2nyra_ appears in SCOPe 2.07
  
• d2nyra_ appears in the current release, SCOPe 2.08