SCOPe 2.01: Domain d2nvua_: 2nvu A:

Lineage for d2nvua_ (2nvu A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

4. Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)
   transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
   the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

5. Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (2 proteins)
   the common fold is elaborated with additional (sub)domains

6. Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
   a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion

7. Species Human (Homo sapiens) [TaxId:9606] [89767] (8 PDB entries)
   Uniprot Q13564

8. Domain d2nvua_: 2nvu A: [138660]
   Other proteins in same PDB: d2nvub1, d2nvub2, d2nvuc1, d2nvui_, d2nvuj_
   automated match to d1tt5a_
   complexed with atp, mg, zn

Details for d2nvua_

PDB Entry: 2nvu, 2.8 Å

PDB Description: structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a trapped ubiquitin-like protein activation complex

PDB Compounds: (A:) NEDD8-activating enzyme E1 regulatory subunit

SCOPe Domain Sequences for d2nvua_:

Sequence; same for both SEQRES and ATOM records:

>d2nvua_ c.111.1.2 (A:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
gkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnq
vsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrft
vvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlr
ldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfr
dlirqgilknengapedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsf
wilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakl
lqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneiv
lylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcr
ygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Timeline for d2nvua_:

• d2nvua_ first appeared in SCOP 1.73, called d2nvua1
  
• d2nvua_ was called d2nvua1 in SCOP 1.75
  
• d2nvua_ appears in SCOPe 2.02
  
• d2nvua_ appears in the current release, SCOPe 2.08