SCOP 1.75: Domain d2ntja1: 2ntj A:3-269

Lineage for d2ntja1 (2ntj A:3-269)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Enoyl-ACP reductase [51791] (6 species)

7. Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (24 PDB entries)

8. Domain d2ntja1: 2ntj A:3-269 [138581]
   automatically matched to d1bvra_
   complexed with p1h; mutant

Details for d2ntja1

PDB Entry: 2ntj, 2.5 Å

PDB Description: mycobacterium tuberculosis inha bound with pth-nad adduct

PDB Compounds: (A:) Enoyl-[acyl-carrier-protein] reductase [NADH

SCOP Domain Sequences for d2ntja1:

Sequence; same for both SEQRES and ATOM records:

>d2ntja1 c.2.1.2 (A:3-269) Enoyl-ACP reductase {Mycobacterium tuberculosis, TB, gene InhA [TaxId: 1773]}
glldgkrilvsgiitdssiafhiarvaqeqgaqlvltgfdrlrliqritdrlpakaplle
ldvqneehlaslagrvteaigagnkldgvvhsigfmpqtgmginpffdapyadvskgihi
saysyasmakallpimnpggsivgmdfdpsrampaynwmtvaksalesvnrfvareagky
gvrsnlvaagpirtlamsaivggalgeeagaqiqlleegwdqrapigwnmkdatpvaktv
callsdwlpattgdiiyadggahtqll

Timeline for d2ntja1:

• d2ntja1 first appeared in SCOP 1.73
  
• d2ntja1 is called d2ntja_ in SCOPe 2.01
  
• d2ntja1 appears in the current release, SCOPe 2.08, called d2ntja2