SCOPe 2.05: Domain d2nqia_: 2nqi A:

Lineage for d2nqia_ (2nqi A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
   automatically mapped to Pfam PF00648

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (6 species)
   includes the N-terminal 'sequence' domain I

7. Species Norway rat (Rattus norvegicus), mu-type [TaxId:10116] [75332] (10 PDB entries)
   Uniprot P97571 33-353

8. Domain d2nqia_: 2nqi A: [138454]
   automated match to d1tloa_
   complexed with ca, nqi

Details for d2nqia_

PDB Entry: 2nqi, 2.04 Å

PDB Description: calpain 1 proteolytic core inactivated by wr13(r,r), an epoxysuccinyl- type inhibitor.

PDB Compounds: (A:) Calpain-1 catalytic subunit

SCOPe Domain Sequences for d2nqia_:

Sequence; same for both SEQRES and ATOM records:

>d2nqia_ d.3.1.3 (A:) Calpain large subunit, catalytic domain (domain II) {Norway rat (Rattus norvegicus), mu-type [TaxId: 10116]}
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnlt

Timeline for d2nqia_:

• d2nqia_ first appeared in SCOP 1.73, called d2nqia1
  
• d2nqia_ appears in SCOPe 2.04
  
• d2nqia_ appears in SCOPe 2.06
  
• d2nqia_ appears in the current release, SCOPe 2.08