SCOP 1.73: Domain d2java1: 2jav A:3-271

Lineage for d2java1 (2jav A:3-271)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Serine/threonine-protein kinase Nek2 [143893] (1 species)
   NIMA subfamily (NimA-related protein kinase 2)

7. Species Human (Homo sapiens) [TaxId:9606] [143894] (1 PDB entry)

8. Domain d2java1: 2jav A:3-271 [138243]
   complexed with 5z5; mutant

Details for d2java1

PDB Entry: 2jav, 2.2 Å

PDB Description: human kinase with pyrrole-indolinone ligand

PDB Compounds: (A:) serine/threonine-protein kinase nek2

SCOP Domain Sequences for d2java1:

Sequence, based on SEQRES records:

>d2java1 d.144.1.7 (A:3-271) Serine/threonine-protein kinase Nek2 {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltl
alkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfakafvgtpyy
mspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyrysd
elneiitrmlnlkdyhrpsveeilenpli

Sequence, based on observed residues (ATOM records):

>d2java1 d.144.1.7 (A:3-271) Serine/threonine-protein kinase Nek2 {Human (Homo sapiens) [TaxId: 9606]}
sraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrel
khpnivryydriidtlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltlalke
chrrsdlkpanvfldgkqnvklgdfglarilgtpyymspeqmnrmsyneksdiwslgcll
yelcalmppftafsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeil
enpli

Timeline for d2java1:

• d2java1 is new in SCOP 1.73
  
• d2java1 appears in SCOP 1.75
  
• d2java1 appears in the current release, SCOPe 2.08