Lineage for d2j5fa_ (2j5f A:)

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. Protein automated matches [190091] (20 species)
    not a true protein
  7. Species Human (Homo sapiens) [TaxId:9606] [188447] (844 PDB entries)
  8. Domain d2j5fa_: 2j5f A: [138035]
    automated match to d3ikaa_
    complexed with djk

Details for d2j5fa_

PDB Entry: 2j5f (more details), 3 Å

PDB Description: crystal structure of egfr kinase domain in complex with an irreversible inhibitor 34-jab
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2j5fa_:

Sequence, based on SEQRES records: (download)

>d2j5fa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipq

Sequence, based on observed residues (ATOM records): (download)

>d2j5fa_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmal
esilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidv
ymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsplmdeedmddvv
dadeylipq

SCOPe Domain Coordinates for d2j5fa_ are not available.

Timeline for d2j5fa_: