SCOPe 2.05: Domain d2iw8d2: 2iw8 D:310-432

Lineage for d2iw8d2 (2iw8 D:310-432)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (75 PDB entries)
   Uniprot P20248 175-432

8. Domain d2iw8d2: 2iw8 D:310-432 [137747]
   Other proteins in same PDB: d2iw8a1, d2iw8c_
   automated match to d1oiub2
   complexed with 4sp, sgm; mutant

Details for d2iw8d2

PDB Entry: 2iw8, 2.3 Å

PDB Description: structure of human thr160-phospho cdk2-cyclin a f82h-l83v-h84d mutant with an o6-cyclohexylmethylguanine inhibitor

PDB Compounds: (D:) Cyclin-A2

SCOPe Domain Sequences for d2iw8d2:

Sequence; same for both SEQRES and ATOM records:

>d2iw8d2 a.74.1.1 (D:310-432) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
tvnqfltqyflhqqpanckveslamflgelslidadpylkylpsviagaafhlalytvtg
qswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyknskyhgvsllnppet
lnl

Timeline for d2iw8d2:

• d2iw8d2 first appeared in SCOP 1.73
  
• d2iw8d2 appears in SCOPe 2.04
  
• d2iw8d2 appears in SCOPe 2.06
  
• d2iw8d2 appears in the current release, SCOPe 2.08