SCOPe 2.06: Domain d2itya1: 2ity A:697-1018

Lineage for d2itya1 (2ity A:697-1018)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (90 PDB entries)
   Uniprot P00533 702-1018

8. Domain d2itya1: 2ity A:697-1018 [137648]
   automatically matched to d1m14a_
   complexed with ire

Details for d2itya1

PDB Entry: 2ity, 3.42 Å

PDB Description: Crystal structure of EGFR kinase domain in complex with Iressa

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2itya1:

Sequence, based on SEQRES records:

>d2itya1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d2itya1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaevpikwmalesi
lhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymi
mvkcwmidadsrpkfreliiefskmardpqrylviqgdermhldeedmddvvdadeyli

Timeline for d2itya1:

• d2itya1 first appeared in SCOP 1.73
  
• d2itya1 appears in SCOPe 2.05
  
• d2itya1 appears in SCOPe 2.07
  
• d2itya1 appears in the current release, SCOPe 2.08