SCOP 1.73: Domain d2itxa1: 2itx A:697-1018

Lineage for d2itxa1 (2itx A:697-1018)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (10 PDB entries)

8. Domain d2itxa1: 2itx A:697-1018 [137647]
   automatically matched to d1m14a_
   complexed with anp

Details for d2itxa1

PDB Entry: 2itx, 2.98 Å

PDB Description: crystal structure of egfr kinase domain in complex with amp-pnp

PDB Compounds: (A:) Epidermal growth factor receptor

SCOP Domain Sequences for d2itxa1:

Sequence, based on SEQRES records:

>d2itxa1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d2itxa1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglaklekeyhaeggkvpikw
malesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppict
idvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlmdeedmddvvd
adeyli

Timeline for d2itxa1:

• d2itxa1 is new in SCOP 1.73
  
• d2itxa1 appears in SCOP 1.75
  
• d2itxa1 appears in the current release, SCOPe 2.08, called d2itxa_