SCOPe 2.01: Domain d2isia1: 2isi A:43-318

Lineage for d2isia1 (2isi A:43-318)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.151: DNase I-like [56218] (1 superfamily)
   contains beta-sandwich; duplication of alpha+beta motif

4. Superfamily d.151.1: DNase I-like [56219] (4 families)

5. Family d.151.1.1: DNase I-like [56220] (7 proteins)

6. Protein DNA repair endonuclease Hap1 [56223] (1 species)
   Major apurinic/apyrimidinic endonuclease APE1

7. Species Human (Homo sapiens) [TaxId:9606] [56224] (7 PDB entries)

8. Domain d2isia1: 2isi A:43-318 [137603]
   automatically matched to d1e9na_
   complexed with mg, po4

Details for d2isia1

PDB Entry: 2isi, 2.76 Å

PDB Description: Crystal structure of Ape1 from Homo sapiens in a new crystal form complexed with a ligand

PDB Compounds: (A:) DNA-(apurinic or apyrimidinic site) lyase

SCOPe Domain Sequences for d2isia1:

Sequence; same for both SEQRES and ATOM records:

>d2isia1 d.151.1.1 (A:43-318) DNA repair endonuclease Hap1 {Human (Homo sapiens) [TaxId: 9606]}
alyedppdqktspsgkpatlkicswnvdglrawikkkgldwvkeeapdilclqetkcsen
klpaelqelpglshqywsapsdkegysgvgllsrqcplkvsygigdeehdqegrvivaef
dsfvlvtayvpnagrglvrleyrqrwdeafrkflkglasrkplvlcgdlnvaheeidlrn
pkgnkknagftpqerqgfgellqavpladsfrhlypntpyaytfwtymmnarsknvgwrl
dyfllshsllpalcdskirskalgsdhcpitlylal

Timeline for d2isia1:

• d2isia1 first appeared in SCOP 1.73
  
• d2isia1 appears in SCOP 1.75
  
• d2isia1 appears in SCOPe 2.02
  
• d2isia1 appears in the current release, SCOPe 2.08, called d2isia_