SCOPe 2.08: Domain d2isfa_: 2isf A:

Lineage for d2isfa_ (2isf A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (156 PDB entries)
   Uniprot P15121

8. Domain d2isfa_: 2isf A: [137602]
   automated match to d1az1__
   complexed with nap, pac

Details for d2isfa_

PDB Entry: 2isf, 2 Å

PDB Description: crystal structure of c298a w219y aldose reductase complexed with phenylacetic acid

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2isfa_:

Sequence; same for both SEQRES and ATOM records:

>d2isfa_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
srlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqek
lreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgkef
fpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpav
nqiechpyltqekliqycqskgivvtaysplgspdrpyakpedpslledprikaiaakhn
kttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvaall
sctshkdypfheef

Timeline for d2isfa_:

• d2isfa_ first appeared in SCOP 1.73, called d2isfa1
  
• d2isfa_ appears in SCOPe 2.07