Lineage for d2irwg1 (2irw G:26-289)

  1. Root: SCOPe 2.03
  2. 1336837Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 1346342Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 1346343Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 1346668Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 1346695Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 1346711Species Human (Homo sapiens) [TaxId:9606] [117424] (24 PDB entries)
    Uniprot P28845
  8. 1346797Domain d2irwg1: 2irw G:26-289 [137599]
    automatically matched to d1xu9b_
    complexed with nap, nn4

Details for d2irwg1

PDB Entry: 2irw (more details), 3.1 Å

PDB Description: human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor
PDB Compounds: (G:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d2irwg1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2irwg1 c.2.1.2 (G:26-289) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2irwg1:

Click to download the PDB-style file with coordinates for d2irwg1.
(The format of our PDB-style files is described here.)

Timeline for d2irwg1: