SCOPe 2.08: Domain d2inza_: 2inz A:

Lineage for d2inza_ (2inz A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (156 PDB entries)
   Uniprot P15121

8. Domain d2inza_: 2inz A: [137535]
   automated match to d1ads__
   complexed with nap, ohp

Details for d2inza_

PDB Entry: 2inz, 1.95 Å

PDB Description: crystal structure of aldose reductase complexed with 2- hydroxyphenylacetic acid

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2inza_:

Sequence; same for both SEQRES and ATOM records:

>d2inza_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
asrlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef

Timeline for d2inza_:

• d2inza_ first appeared in SCOP 1.73, called d2inza1
  
• d2inza_ appears in SCOPe 2.07