SCOPe 2.08: Domain d2imaa2: 2ima A:1-418

Lineage for d2imaa2 (2ima A:1-418)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (29 PDB entries)
   Uniprot P10845 1-419

8. Domain d2imaa2: 2ima A:1-418 [137509]
   Other proteins in same PDB: d2imaa3, d2imab3
   automated match to d1xtga_
   complexed with gb4, zn

Details for d2imaa2

PDB Entry: 2ima, 1.94 Å

PDB Description: clostridium botulinum neurotoxin serotype a light chain inhibited by 2,4-dichlorocinnamic hydroxamate

PDB Compounds: (A:) Botulinum neurotoxin A light-chain

SCOPe Domain Sequences for d2imaa2:

Sequence, based on SEQRES records:

>d2imaa2 d.92.1.7 (A:1-418) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
mqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihnkiwviperdtftnpeegdln
pppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwgg
stidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngy
gstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainpn
rvfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnka
ksivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkv
lnrktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklkn

Sequence, based on observed residues (ATOM records):

>d2imaa2 d.92.1.7 (A:1-418) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
mqfvnkqfnykdpvngvdiayikipmqpvkafkihnkiwviperdtftnpeegdlnppvp
vsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggstidtelkv
idtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngygstqyirfs
pdftfgfeeslenpllgagkfatdpavtlahelihaghrlygiainpnrvfkevsfeelr
tfgghdakfidslqenefrlyyynkfkdiastlnkaksivgaslqymknvfkekyllsed
tsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnyti
ydgfnlrntnlaanfngqnteinnmnftklkn

Timeline for d2imaa2:

• d2imaa2 first appeared in SCOP 1.73, called d2imaa1
  
• d2imaa2 appears in SCOPe 2.07