SCOPe 2.08: Domain d2iehb_: 2ieh B:

Lineage for d2iehb_ (2ieh B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.9: Motor proteins [52641] (5 proteins)

6. Protein automated matches [190129] (6 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187145] (33 PDB entries)

8. Domain d2iehb_: 2ieh B: [137310]
   automated match to d1q0bb_
   complexed with adp, cl, k, mg, moy, pg4

Details for d2iehb_

PDB Entry: 2ieh, 2.7 Å

PDB Description: Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer

PDB Compounds: (B:) Kinesin-like protein KIF11

SCOPe Domain Sequences for d2iehb_:

Sequence, based on SEQRES records:

>d2iehb_ c.37.1.9 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagsenigrsgavdkrareagninqslltlgrvitalvertphvpyresk
ltrilqdslggrtrtsiiatispaslnleetlstleyahraknilnkpevn

Sequence, based on observed residues (ATOM records):

>d2iehb_ c.37.1.9 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagseninqslltlgrvitalvertphvpyreskltrilqdslggrtrts
iiatispaslnleetlstleyahraknilnkpevn

Timeline for d2iehb_:

• d2iehb_ first appeared in SCOP 1.73, called d2iehb1
  
• d2iehb_ appears in SCOPe 2.07