SCOPe 2.06: Domain d2i5yq2: 2i5y Q:108-212

Lineage for d2i5yq2 (2i5y Q:108-212)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d2i5yq2: 2i5y Q:108-212 [137078]
   Other proteins in same PDB: d2i5yg2, d2i5yg3, d2i5yh1, d2i5yh2, d2i5yl1, d2i5ym1, d2i5yp2, d2i5yp3, d2i5yq1, d2i5yr1, d2i5yr2, d2i5ys1
   automatically matched to d1g9ml2
   complexed with nag, ndg

Details for d2i5yq2

PDB Entry: 2i5y, 2.2 Å

PDB Description: crystal structure of cd4m47, a scorpion-toxin mimic of cd4, in complex with hiv-1 yu2 gp120 envelope glycoprotein and anti-hiv-1 antibody 17b

PDB Compounds: (Q:) Antibody 17B Light chain

SCOPe Domain Sequences for d2i5yq2:

Sequence; same for both SEQRES and ATOM records:

>d2i5yq2 b.1.1.2 (Q:108-212) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrg

Timeline for d2i5yq2:

• d2i5yq2 first appeared in SCOP 1.73
  
• d2i5yq2 appears in SCOPe 2.05
  
• d2i5yq2 appears in SCOPe 2.07
  
• d2i5yq2 appears in the current release, SCOPe 2.08