SCOP 1.75: Domain d2i47b1: 2i47 B:221-473

Lineage for d2i47b1 (2i47 B:221-473)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (17 families)

5. Family d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (1 protein)

6. Protein TNF-alpha converting enzyme, TACE, catalytic domain [55526] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55527] (7 PDB entries)

8. Domain d2i47b1: 2i47 B:221-473 [137046]
   automatically matched to d1bkca_
   complexed with inn, kgy, zn; mutant

Details for d2i47b1

PDB Entry: 2i47, 1.9 Å

PDB Description: crystal structure of catalytic domain of tace with inhibitor

PDB Compounds: (B:) adam 17

SCOP Domain Sequences for d2i47b1:

Sequence; same for both SEQRES and ATOM records:

>d2i47b1 d.92.1.10 (B:221-473) TNF-alpha converting enzyme, TACE, catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
mkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqie
qirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlfty
qdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktiltkead
lvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiyk
tieskaqecfqer

Timeline for d2i47b1:

• d2i47b1 first appeared in SCOP 1.73
  
• d2i47b1 appears in SCOPe 2.01
  
• d2i47b1 appears in the current release, SCOPe 2.08, called d2i47b_