SCOP 1.73: Domain d2i1rb1: 2i1r B:1-564

Lineage for d2i1rb1 (2i1r B:1-564)

1. Root: SCOP 1.73

2. Class e: Multi-domain proteins (alpha and beta) [56572] (53 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (2 proteins)

6. Protein Viral RNA polymerase [56695] (9 species)

7. Species Hepatitis C virus [TaxId:11103] [56697] (21 PDB entries)

8. Domain d2i1rb1: 2i1r B:1-564 [136987]
   automatically matched to d1c2pb_
   complexed with vxr

Details for d2i1rb1

PDB Entry: 2i1r, 2.2 Å

PDB Description: Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure

PDB Compounds: (B:) RNA-directed RNA polymerase (NS5B) (p68)

SCOP Domain Sequences for d2i1rb1:

Sequence, based on SEQRES records:

>d2i1rb1 e.8.1.4 (B:1-564) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyhsl

Sequence, based on observed residues (ATOM records):

>d2i1rb1 e.8.1.4 (B:1-564) Viral RNA polymerase {Hepatitis C virus [TaxId: 11103]}
hhsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqv
vmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdl
apearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacra
aklqdctmlvngddlvvicesagvqedaaslrafteamtrysappgdppqpeydlelits
cssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmil
mthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrv
asclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasql
dlsgwfvagysggdiyhsl

Timeline for d2i1rb1:

• d2i1rb1 is new in SCOP 1.73
  
• d2i1rb1 appears in SCOP 1.75
  
• d2i1rb1 appears in the current release, SCOPe 2.08, called d2i1rb2