SCOP 1.73: Domain d2i17a1: 2i17 A:2-314

Lineage for d2i17a1 (2i17 A:2-314)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (53 PDB entries)

8. Domain d2i17a1: 2i17 A:2-314 [136979]
   automatically matched to d1pwla_
   complexed with cit, ldt, ndp

Details for d2i17a1

PDB Entry: 2i17, 0.81 Å

PDB Description: Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K

PDB Compounds: (A:) aldose reductase

SCOP Domain Sequences for d2i17a1:

Sequence, based on SEQRES records:

>d2i17a1 c.1.7.1 (A:2-314) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfhe

Sequence, based on observed residues (ATOM records):

>d2i17a1 c.1.7.1 (A:2-314) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpdpslledprikaiaakhn
kttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcall
sctshkdypfhe

Timeline for d2i17a1:

• d2i17a1 is new in SCOP 1.73
  
• d2i17a1 appears in SCOP 1.75
  
• d2i17a1 appears in the current release, SCOPe 2.08, called d2i17a_