SCOPe 2.08: Domain d2i16a_: 2i16 A:

Lineage for d2i16a_ (2i16 A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein automated matches [190169] (7 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188399] (46 PDB entries)

8. Domain d2i16a_: 2i16 A: [136978]
   automated match to d1pwla_
   complexed with cit, ldt, ndp

Details for d2i16a_

PDB Entry: 2i16, 0.81 Å

PDB Description: Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2i16a_:

Sequence, based on SEQRES records:

>d2i16a_ c.1.7.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfhe

Sequence, based on observed residues (ATOM records):

>d2i16a_ c.1.7.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpdpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfhe

Timeline for d2i16a_:

• d2i16a_ first appeared in SCOP 1.73, called d2i16a1
  
• d2i16a_ appears in SCOPe 2.07