SCOPe 2.08: Domain d2i0gb_: 2i0g B:

Lineage for d2i0gb_ (2i0g B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor beta [48521] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48522] (27 PDB entries)

8. Domain d2i0gb_: 2i0g B: [136951]
   automated match to d1l2jb_
   complexed with i0g

Details for d2i0gb_

PDB Entry: 2i0g, 2.5 Å

PDB Description: benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of benign prostatic hyperplasia

PDB Compounds: (B:) Estrogen receptor beta

SCOPe Domain Sequences for d2i0gb_:

Sequence, based on SEQRES records:

>d2i0gb_ a.123.1.1 (B:) Estrogen receptor beta {Human (Homo sapiens) [TaxId: 9606]}
ldalspeqlvltlleaepphvlisrpsapfteasmmmsltkladkelvhmiswakkipgf
velslfdqvrllescwmevlmmglmwrsidhpgklifapdlvldrdegkcvegileifdm
llattsrfrelklqhkeylcvkamillnssmyplvtatqdadssrklahllnavtdalvw
viaksgissqqqsmrlanllmllshvrhasnkgmehllnmkcknvvpvydlllemlnah

Sequence, based on observed residues (ATOM records):

>d2i0gb_ a.123.1.1 (B:) Estrogen receptor beta {Human (Homo sapiens) [TaxId: 9606]}
ldalspeqlvltlleaepphvlisrpasmmmsltkladkelvhmiswakkipgfvelslf
dqvrllescwmevlmmglmwrsidhpgklifapdlvldrdegkcvegileifdmllatts
rfrelklqhkeylcvkamillnssmyplvssrklahllnavtdalvwviaksgissqqqs
mrlanllmllshvrhasnkgmehllnmkvpvydlllemlnah

Timeline for d2i0gb_:

• d2i0gb_ first appeared in SCOP 1.73, called d2i0gb1
  
• d2i0gb_ appears in SCOPe 2.07