SCOPe 2.07: Domain d2i0ga_: 2i0g A:

Lineage for d2i0ga_ (2i0g A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor beta [48521] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48522] (27 PDB entries)

8. Domain d2i0ga_: 2i0g A: [136950]
   automated match to d1l2jb_
   complexed with i0g

Details for d2i0ga_

PDB Entry: 2i0g, 2.5 Å

PDB Description: benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of benign prostatic hyperplasia

PDB Compounds: (A:) Estrogen receptor beta

SCOPe Domain Sequences for d2i0ga_:

Sequence, based on SEQRES records:

>d2i0ga_ a.123.1.1 (A:) Estrogen receptor beta {Human (Homo sapiens) [TaxId: 9606]}
dalspeqlvltlleaepphvlisrpsapfteasmmmsltkladkelvhmiswakkipgfv
elslfdqvrllescwmevlmmglmwrsidhpgklifapdlvldrdegkcvegileifdml
lattsrfrelklqhkeylcvkamillnssmyplvtatqdadssrklahllnavtdalvwv
iaksgissqqqsmrlanllmllshvrhasnkgmehllnmkcknvvpvydlllemlnah

Sequence, based on observed residues (ATOM records):

>d2i0ga_ a.123.1.1 (A:) Estrogen receptor beta {Human (Homo sapiens) [TaxId: 9606]}
dalspeqlvltlleaepphvlisrpasmmmsltkladkelvhmiswakkipgfvelslfd
qvrllescwmevlmmglmwrsidhpgklifapdlvldrdegkcvegileifdmllattsr
frelklqhkeylcvkamillnssmyplvssrklahllnavtdalvwviaksgissqqqsm
rlanllmllshvrhasnkgmehllnmkvpvydlllemlnah

Timeline for d2i0ga_:

• d2i0ga_ first appeared in SCOP 1.73, called d2i0ga1
  
• d2i0ga_ appears in SCOPe 2.06
  
• d2i0ga_ appears in the current release, SCOPe 2.08