SCOPe 2.05: Domain d2hxzc_: 2hxz C:

Lineage for d2hxzc_ (2hxz C:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (23 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.1: Papain-like [54002] (26 proteins)

6. Protein (Pro)cathepsin S [82566] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82567] (23 PDB entries)

8. Domain d2hxzc_: 2hxz C: [136863]
   automated match to d1ms6a_
   complexed with h7j, so4

Details for d2hxzc_

PDB Entry: 2hxz, 1.9 Å

PDB Description: Crystal Structure of Cathepsin S in complex with a Nonpeptidic Inhibitor (Hexagonal spacegroup)

PDB Compounds: (C:) cathepsin S

SCOPe Domain Sequences for d2hxzc_:

Sequence; same for both SEQRES and ATOM records:

>d2hxzc_ d.3.1.1 (C:) (Pro)cathepsin S {Human (Homo sapiens) [TaxId: 9606]}
lpdsvdwrekgcvtevkyqgscgacwafsavgaleaqlklktgklvslsaqnlvdcstek
ygnkgcnggfmttafqyiidnkgidsdasypykamdqkcqydskyraatcskytelpygr
edvlkeavankgpvsvgvdarhpsfflyrsgvyyepsctqnvnhgvlvvgygdlngkeyw
lvknswghnfgeegyirmarnkgnhcgiasfpsypei

Timeline for d2hxzc_:

• d2hxzc_ first appeared in SCOP 1.73, called d2hxzc1
  
• d2hxzc_ appears in SCOPe 2.04
  
• d2hxzc_ appears in SCOPe 2.06
  
• d2hxzc_ appears in the current release, SCOPe 2.08