Lineage for d2hvoa1 (2hvo A:1-315)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 814174Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 815099Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (1 family) (S)
  5. 815100Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (15 proteins)
    Common fold covers whole protein structure
  6. 815141Protein Aldose reductase (aldehyde reductase) [51436] (2 species)
  7. 815142Species Human (Homo sapiens) [TaxId:9606] [51437] (57 PDB entries)
    Uniprot P15121
  8. 815173Domain d2hvoa1: 2hvo A:1-315 [136815]
    automatically matched to d1pwla_
    complexed with nap, zst

Details for d2hvoa1

PDB Entry: 2hvo (more details), 1.65 Å

PDB Description: Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst)
PDB Compounds: (A:) aldose reductase

SCOP Domain Sequences for d2hvoa1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2hvoa1 c.1.7.1 (A:1-315) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef

SCOP Domain Coordinates for d2hvoa1:

Click to download the PDB-style file with coordinates for d2hvoa1.
(The format of our PDB-style files is described here.)

Timeline for d2hvoa1: