SCOPe 2.08: Domain d2hleb_: 2hle B:

Lineage for d2hleb_ (2hle B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.6: Cupredoxin-like [49502] (2 superfamilies)
   sandwich; 7 strands in 2 sheets, greek-key
   variations: some members have additional 1-2 strands

4. Superfamily b.6.1: Cupredoxins [49503] (8 families)
   contains copper-binding site

5. Family b.6.1.5: Ephrin ectodomain [74874] (3 proteins)
   eukaryotic signaling domain probably related to cupredoxins but lacking the metal-binding site
   automatically mapped to Pfam PF00812

6. Protein Ephrin-b2 ectodomain [74875] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [190026] (4 PDB entries)

8. Domain d2hleb_: 2hle B: [136565]
   Other proteins in same PDB: d2hlea1, d2hlea2
   automated match to d1ikop_

Details for d2hleb_

PDB Entry: 2hle, 2.05 Å

PDB Description: structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity.

PDB Compounds: (B:) ephrin-b2

SCOPe Domain Sequences for d2hleb_:

Sequence, based on SEQRES records:

>d2hleb_ b.6.1.5 (B:) Ephrin-b2 ectodomain {Human (Homo sapiens) [TaxId: 9606]}
ivlepiywnssnskflpgqglvlypqigdkldiicpkvdsktvgqyeyykvymvdkdqad
rctikkentpllncarpdqdvkftikfqefspnlwglefqknkdyyiistsngslegldn
qeggvcqtramkilmkvg

Sequence, based on observed residues (ATOM records):

>d2hleb_ b.6.1.5 (B:) Ephrin-b2 ectodomain {Human (Homo sapiens) [TaxId: 9606]}
ivlepiywnssnskflpgqglvlypqigdkldiicpkvdsktvqyeyykvymvdkdqadr
ctikpllncarpdqdvkftikfqefspnlwglefqknkdyyiistsngslegldnqeggv
cqtramkilmkvg

Timeline for d2hleb_:

• d2hleb_ first appeared in SCOP 1.73, called d2hleb1
  
• d2hleb_ appears in SCOPe 2.07