SCOPe 2.07: Domain d2hfja_: 2hfj A:

Lineage for d2hfja_ (2hfj A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.22: Thioesterase domain of polypeptide, polyketide and fatty acid synthases [69584] (4 proteins)
   Pfam PF00975

6. Protein Picromycin polyketide synthase [82513] (1 species)

7. Species Streptomyces venezuelae [TaxId:54571] [82514] (7 PDB entries)

8. Domain d2hfja_: 2hfj A: [136386]
   automated match to d1mnab_
   complexed with dms, mg, so4, yml

Details for d2hfja_

PDB Entry: 2hfj, 1.95 Å

PDB Description: pikromycin thioesterase with covalent pentaketide affinity label

PDB Compounds: (A:) Type I polyketide synthase PikAIV

SCOPe Domain Sequences for d2hfja_:

Sequence, based on SEQRES records:

>d2hfja_ c.69.1.22 (A:) Picromycin polyketide synthase {Streptomyces venezuelae [TaxId: 54571]}
agmfralfrqaveddrygefldvlaeasafrpqfaspeacserldpvllaggptdraegr
avlvgctgtaanggpheflrlstsfqeerdflavplpgygtgtgtgtallpadldtalda
qarailraagdapvvllghsggallahelafrlerahgappagivlvdpyppghqepiev
wsrqlgeglfagelepmsdarllamgryarflagprpgrssapvllvraseplgdwqeer
gdwrahwdlphtvadvpgdhftmmrdhapavaeavlswldaieg

Sequence, based on observed residues (ATOM records):

>d2hfja_ c.69.1.22 (A:) Picromycin polyketide synthase {Streptomyces venezuelae [TaxId: 54571]}
agmfralfrqaveddrygefldvlaeasafrpqfaspeacserldpvllaggptdegrav
lvgctgtaanggpheflrlstsfqeerdflavplpgygtggtallpadldtaldaqarai
lraagdapvvllghsggallahelafrlerahgappagivlvdpyppghqepievwsrql
geglfagelepmsdarllamgryarflagprpgrssapvllvraseplgdwqeergdwra
hwdlphtvadvpgdhftmmrdhapavaeavlswldaieg

Timeline for d2hfja_:

• d2hfja_ first appeared in SCOP 1.73, called d2hfja1
  
• d2hfja_ appears in SCOPe 2.06
  
• d2hfja_ appears in the current release, SCOPe 2.08