Lineage for d2hala1 (2hal A:1-212)

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 802045Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 802046Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 803590Family b.47.1.4: Viral cysteine protease of trypsin fold [50603] (3 proteins)
  6. 803595Protein 3C cysteine protease (picornain 3C) [50604] (4 species)
  7. 803601Species Human hepatitis A virus [TaxId:208726] [50606] (7 PDB entries)
  8. 803604Domain d2hala1: 2hal A:1-212 [136289]
    automatically matched to d1hava_
    complexed with ace, bbl, eke, mke; mutant

Details for d2hala1

PDB Entry: 2hal (more details), 1.35 Å

PDB Description: An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
PDB Compounds: (A:) Hepatitis A Protease 3C

SCOP Domain Sequences for d2hala1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2hala1 b.47.1.4 (A:1-212) 3C cysteine protease (picornain 3C) {Human hepatitis A virus [TaxId: 208726]}
stleiaglvrknlvqfgvgekngsvrwvmnalgvkddwllvpshaykfekdyemmefyfn
rggtyysisagnvviqsldvgfqdvvlmkvptipkfrditqhfikkgdvpralnrlatlv
ttvngtpmlisegplkmeekatyvhkkndgttvdltvdqawrgkgeglpgmcggalvssn
qsiqnailgihvaggnsilvaklvtqemfqni

SCOP Domain Coordinates for d2hala1:

Click to download the PDB-style file with coordinates for d2hala1.
(The format of our PDB-style files is described here.)

Timeline for d2hala1: