SCOP 1.73: Domain d2h4ga1: 2h4g A:2-283

Lineage for d2h4ga1 (2h4g A:2-283)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (5 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (6 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein Tyrosine phosphatase [52806] (7 species)

7. Species Human (Homo sapiens), 1B [TaxId:9606] [52807] (91 PDB entries)

8. Domain d2h4ga1: 2h4g A:2-283 [136074]
   automatically matched to d1ptta_
   complexed with 694

Details for d2h4ga1

PDB Entry: 2h4g, 2.5 Å

PDB Description: Crystal structure of PTP1B with monocyclic thiophene inhibitor

PDB Compounds: (A:) tyrosine-protein phosphatase non-receptor type 1

SCOP Domain Sequences for d2h4ga1:

Sequence; same for both SEQRES and ATOM records:

>d2h4ga1 c.45.1.2 (A:2-283) Tyrosine phosphatase {Human (Homo sapiens), 1B [TaxId: 9606]}
emekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklhq
edndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslkc
aqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwpd
fgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkdp
ssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimg

Timeline for d2h4ga1:

• d2h4ga1 is new in SCOP 1.73
  
• d2h4ga1 appears in SCOP 1.75
  
• d2h4ga1 appears in the current release, SCOPe 2.08, called d2h4ga_