SCOP 1.75: Domain d2h2ha1: 2h2h A:1-245

Lineage for d2h2ha1 (2h2h A:1-245)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (6 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (7 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein NAD-dependent deacetylase NpdA [142126] (1 species)

7. Species Thermotoga maritima [TaxId:2336] [142127] (10 PDB entries)
   Uniprot Q9WYW0 1-245

8. Domain d2h2ha1: 2h2h A:1-245 [136006]
   automatically matched to 1YC5 A:1-245
   complexed with zn

Details for d2h2ha1

PDB Entry: 2h2h, 2.2 Å

PDB Description: the structural basis of sirtuin substrate specificity

PDB Compounds: (A:) NAD-dependent deacetylase

SCOP Domain Sequences for d2h2ha1:

Sequence, based on SEQRES records:

>d2h2ha1 c.31.1.5 (A:1-245) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfrgpngiykkysqnvfdidffyshpeef
yrfakegifpmlqakpnlahvllakleekglieavitqnidrlhqragskkvielhgnve
eyycvrcekkytvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssr
aslmivlgsslvvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvm
eeggi

Sequence, based on observed residues (ATOM records):

>d2h2ha1 c.31.1.5 (A:1-245) NAD-dependent deacetylase NpdA {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfnvfdidffyshpeefyrfakegifpml
qakpnlahvllakleekglieavitqnidrlhqragskkvielhgnveeyycvrcekkyt
vedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssraslmivlgsslv
vypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvmeeggi

Timeline for d2h2ha1:

• d2h2ha1 first appeared in SCOP 1.73
  
• d2h2ha1 is called d2h2ha_ in SCOPe 2.01
  
• d2h2ha1 appears in the current release, SCOPe 2.08, called d2h2ha_