SCOPe 2.05: Domain d2h2da_: 2h2d A:

Lineage for d2h2da_ (2h2d A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.0: automated matches [191352] (1 protein)
   not a true family

6. Protein automated matches [190312] (9 species)
   not a true protein

7. Species Thermotoga maritima [TaxId:2336] [187125] (7 PDB entries)

8. Domain d2h2da_: 2h2d A: [135997]
   automated match to d1ma3a_
   complexed with zn

Details for d2h2da_

PDB Entry: 2h2d, 1.7 Å

PDB Description: the structural basis for sirtuin substrate affinity

PDB Compounds: (A:) NAD-dependent deacetylase

SCOPe Domain Sequences for d2h2da_:

Sequence, based on SEQRES records:

>d2h2da_ c.31.1.0 (A:) automated matches {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfrgpngiykkysqnvfdidffyshpeef
yrfakegifpmlqakpnlahvllakleekglieavitqnidrlhqragskkvielhgnve
eyycvrcekkytvedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssr
aslmivlgsslvvypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvm
eeggis

Sequence, based on observed residues (ATOM records):

>d2h2da_ c.31.1.0 (A:) automated matches {Thermotoga maritima [TaxId: 2336]}
mkmkefldllnesrltvtltgagistpsgipdfnvfdidffyshpeefyrfakegifpml
qakpnlahvllakleekglieavitqnidrlhqragskkvielhgnveeyycvrcekkyt
vedvikklessdvplcddcnslirpnivffgenlpqdalreaiglssraslmivlgsslv
vypaaelplitvrsggklvivnlgetpfddiatlkynmdvvefarrvmeeggis

Timeline for d2h2da_:

• d2h2da_ first appeared in SCOP 1.73, called d2h2da1
  
• d2h2da_ appears in SCOPe 2.04
  
• d2h2da_ appears in SCOPe 2.06
  
• d2h2da_ appears in the current release, SCOPe 2.08