Lineage for d2h24a1 (2h24 A:18-159)

  1. Root: SCOP 1.73
  2. 631650Class a: All alpha proteins [46456] (258 folds)
  3. 639436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 639437Superfamily a.26.1: 4-helical cytokines [47266] (3 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 639600Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (8 proteins)
    contains an additional helix in one of the crossover connections
  6. 639648Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
  7. 639652Species Human (Homo sapiens) [TaxId:9606] [47307] (7 PDB entries)
  8. 639657Domain d2h24a1: 2h24 A:18-159 [135988]
    automatically matched to d2ilk__

Details for d2h24a1

PDB Entry: 2h24 (more details), 2 Å

PDB Description: Crystal structure of human IL-10
PDB Compounds: (A:) interleukin-10

SCOP Domain Sequences for d2h24a1:

Sequence, based on SEQRES records: (download)

>d2h24a1 a.26.1.3 (A:18-159) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d2h24a1 a.26.1.3 (A:18-159) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]}

SCOP Domain Coordinates for d2h24a1:

Click to download the PDB-style file with coordinates for d2h24a1.
(The format of our PDB-style files is described here.)

Timeline for d2h24a1: