SCOPe 2.01: Domain d2gv7a_: 2gv7 A:

Lineage for d2gv7a_ (2gv7 A:)

1. Root: SCOPe 2.01

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Matriptase MTSP1 [69284] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69285] (7 PDB entries)

8. Domain d2gv7a_: 2gv7 A: [135758]
   automated match to d1eawa_
   complexed with 672

Details for d2gv7a_

PDB Entry: 2gv7, 2.2 Å

PDB Description: Structure of Matriptase in Complex with Inhibitor CJ-672

PDB Compounds: (A:) suppressor of tumorigenicity 14

SCOPe Domain Sequences for d2gv7a_:

Sequence; same for both SEQRES and ATOM records:

>d2gv7a_ b.47.1.2 (A:) Matriptase MTSP1 {Human (Homo sapiens) [TaxId: 9606]}
vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpiclpd
ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
v

Timeline for d2gv7a_:

• d2gv7a_ first appeared in SCOP 1.73, called d2gv7a1
  
• d2gv7a_ was called d2gv7a1 in SCOP 1.75
  
• d2gv7a_ appears in SCOPe 2.02
  
• d2gv7a_ appears in the current release, SCOPe 2.08