SCOPe 2.05: Domain d2gv6a_: 2gv6 A:

Lineage for d2gv6a_ (2gv6 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Matriptase MTSP1 [69284] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [69285] (18 PDB entries)

8. Domain d2gv6a_: 2gv6 A: [135757]
   automated match to d1eawa_
   complexed with 730

Details for d2gv6a_

PDB Entry: 2gv6, 2.1 Å

PDB Description: crystal structure of matriptase with inhibitor cj-730

PDB Compounds: (A:) suppressor of tumorigenicity 14

SCOPe Domain Sequences for d2gv6a_:

Sequence; same for both SEQRES and ATOM records:

>d2gv6a_ b.47.1.2 (A:) Matriptase MTSP1 {Human (Homo sapiens) [TaxId: 9606]}
vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpiclpd
ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
v

Timeline for d2gv6a_:

• d2gv6a_ first appeared in SCOP 1.73, called d2gv6a1
  
• d2gv6a_ appears in SCOPe 2.04
  
• d2gv6a_ appears in SCOPe 2.06
  
• d2gv6a_ appears in the current release, SCOPe 2.08