SCOP 1.75: Domain d2gv2a1: 2gv2 A:25-109

Lineage for d2gv2a1 (2gv2 A:25-109)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (1 family)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (4 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (6 PDB entries)

8. Domain d2gv2a1: 2gv2 A:25-109 [135756]
   automatically matched to d1ycra_
   complexed with 1ac, 6cw, ace, pm3

Details for d2gv2a1

PDB Entry: 2gv2, 1.8 Å

PDB Description: MDM2 in complex with an 8-mer p53 peptide analogue

PDB Compounds: (A:) ubiquitin-protein ligase e3 mdm2

SCOP Domain Sequences for d2gv2a1:

Sequence; same for both SEQRES and ATOM records:

>d2gv2a1 a.42.1.1 (A:25-109) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
etlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivycsndllgd
lfgvpsfsvkehrkiytmiyrnlvv

Timeline for d2gv2a1:

• d2gv2a1 first appeared in SCOP 1.73
  
• d2gv2a1 is called d2gv2a_ in SCOPe 2.01
  
• d2gv2a1 appears in the current release, SCOPe 2.08, called d2gv2a_