SCOPe 2.08: Domain d2gs6a2: 2gs6 A:672-995

Lineage for d2gs6a2 (2gs6 A:672-995)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (133 PDB entries)
   Uniprot P00533 702-1018

8. Domain d2gs6a2: 2gs6 A:672-995 [135578]
   Other proteins in same PDB: d2gs6a3
   automated match to d1m14a_
   complexed with 112, cl

Details for d2gs6a2

PDB Entry: 2gs6, 2.6 Å

PDB Description: crystal structure of the active egfr kinase domain in complex with an atp analog-peptide conjugate

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2gs6a2:

Sequence, based on SEQRES records:

>d2gs6a2 d.144.1.7 (A:672-995) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d2gs6a2 d.144.1.7 (A:672-995) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikeltspkanke
ildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwc
vqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpi
kwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppi
ctidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsedmddvv
dadeylip

Timeline for d2gs6a2:

• d2gs6a2 first appeared in SCOP 1.73, called d2gs6a1
  
• d2gs6a2 appears in SCOPe 2.07