SCOPe 2.01: Domain d2gm1d_: 2gm1 D:

Lineage for d2gm1d_ (2gm1 D:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.9: Motor proteins [52641] (5 proteins)

6. Protein Kinesin [52646] (7 species)

7. Species Human (Homo sapiens), mitotic kinesin eg5 [TaxId:9606] [64018] (8 PDB entries)

8. Domain d2gm1d_: 2gm1 D: [135352]
   automated match to d1q0bb_
   complexed with 2az, adp, mg

Details for d2gm1d_

PDB Entry: 2gm1, 2.3 Å

PDB Description: crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4- dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4- methylbenzamide

PDB Compounds: (D:) kinesin-related motor protein eg5

SCOPe Domain Sequences for d2gm1d_:

Sequence, based on SEQRES records:

>d2gm1d_ c.37.1.9 (D:) Kinesin {Human (Homo sapiens), mitotic kinesin eg5 [TaxId: 9606]}
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgas
tkqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagi
iprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvi
ikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeel
vkigklnlvdlagsenigrsgavdkrareagninqslltlgrvitalvertphvpyresk
ltrilqdslggrtrtsiiatispaslnleetlstleyahraknilnkpevnq

Sequence, based on observed residues (ATOM records):

>d2gm1d_ c.37.1.9 (D:) Kinesin {Human (Homo sapiens), mitotic kinesin eg5 [TaxId: 9606]}
gkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtgglkssrktytfdmvfgastk
qidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagiip
rtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviik
gleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkvkigklnlvdl
agseninqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispasln
leetlstleyahraknilnkpevnq

Timeline for d2gm1d_:

• d2gm1d_ first appeared in SCOP 1.73, called d2gm1d1
  
• d2gm1d_ was called d2gm1d1 in SCOP 1.75
  
• d2gm1d_ appears in SCOPe 2.02
  
• d2gm1d_ appears in the current release, SCOPe 2.08