SCOPe 2.08: Domain d2gjxf1: 2gjx F:200-552

Lineage for d2gjxf1 (2gjx F:200-552)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.6: beta-N-acetylhexosaminidase catalytic domain [51550] (6 proteins)
   Glycosyl hydrolase family 20, GH20
   automatically mapped to Pfam PF00728

6. Protein beta-hexosaminidase B [89486] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89487] (6 PDB entries)

8. Domain d2gjxf1: 2gjx F:200-552 [135315]
   Other proteins in same PDB: d2gjxa1, d2gjxa2, d2gjxb2, d2gjxc2, d2gjxd1, d2gjxd2, d2gjxe1, d2gjxe2, d2gjxf2, d2gjxg2, d2gjxh1, d2gjxh2
   automated match to d1np0a1
   complexed with nag, so4

Details for d2gjxf1

PDB Entry: 2gjx, 2.8 Å

PDB Description: crystallographic structure of human beta-hexosaminidase a

PDB Compounds: (F:) beta-hexosaminidase beta chain

SCOPe Domain Sequences for d2gjxf1:

Sequence, based on SEQRES records:

>d2gjxf1 c.1.8.6 (F:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysrqnkldsf
gpinptlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtd
fkklesfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtas
gfpvilsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnlt
prlwprasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Sequence, based on observed residues (ATOM records):

>d2gjxf1 c.1.8.6 (F:200-552) beta-hexosaminidase B {Human (Homo sapiens) [TaxId: 9606]}
fshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddqsfpyqsitfpelsnkgs
yslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgqkdlltpcysdsfgpinp
tlnttysflttffkeisevfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkkle
sfyiqkvldiiatinkgsivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvi
lsapwyldlisygqdwrkyykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwp
rasavgerlwsskdvrdmddaydrltrhrcrmvergiaaqplyagycn

Timeline for d2gjxf1:

• d2gjxf1 first appeared in SCOP 1.73
  
• d2gjxf1 appears in SCOPe 2.07